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FDA

Regulatory intelligence
FDAsafety guidance72% confidence

Quantitative Systems Pharmacology (QSP)-Based Dose Selection for Minimum Anticipated Biological Effect Level (MABEL) in First-in-Human (FIH) Trials

Source: FDA

Why This Matters

Why this matters: sets a safety guidance precedent in the same sub-indication (immunology) as AbbVie.

Regulatory Analysis

Supporting Context

Therapeutic area
Dermatology · Atopic Dermatitis
Sub-indication
Immunology

Related signal: AbbVie Trials Upadacitinib for Moderate-to-Severe Atopic Dermatitis in Dupilumab Inadequate Responders

Source

View source document

Related Signal

Open signal — AbbVie Trials Upadacitinib for Moderate-to-Severe Atopic Dermatitis in Dupilumab Inadequate Responders
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