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FDA

Regulatory intelligence
FDAsafety guidance83% confidence

Hepatitis C Medicines (Mavyret, Zepatier, and Vosevi): Drug Safety Communication - Due to Rare Occurrence of Serious Liver Injury in Some patients with Advanced Liver Disease

Source: FDA

Why This Matters

Why this matters: illustrates how regulators handled a comparable safety guidance decision relevant to Sandoz.

Regulatory Analysis

FDA has received reports that the use of Mavyret, Zepatier, or Vosevi to treat chronic Hepatitis C in patients with moderate to severe liver impairment has resulted in rare cases of worsening liver function or liver failure.

Supporting Context

Therapeutic area
Cardiovascular · Anticoagulant
Sub-indication
General

Related signal: Sandoz Issues Class 4 Medicines Defect Notification for Apixaban Tablets

Source

View source document

Related Signal

Open signal — Sandoz Issues Class 4 Medicines Defect Notification for Apixaban Tablets
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